Sven-Goran Eriksson admitted Michael Owen's hopes of playing any further part in the World Cup "did not look good" after he was taken off on a stretcher in the first minute of England's 2-2 draw against Sweden.
Owen, who missed the second half of last season with a broken metatarsal, will go for a scan on his injured right knee tomorrow after collapsing in agony close to the touchline.
But, as England booked themselves a knockout match with Ecuador in Stuttgart on Sunday, it looked as if his injury jinx had struck again and his World Cup was over.
Eriksson said: "He is going to have a scan tomorrow and after that we'll see. It doesn't look very good for him and for us.
"He is not happy at all. It doesn't look good and how much time it will take we don't know.
"I think it's a bad one. We'll have to see what the doctors say. It's unfortunate for him and for us."
Man of the match Joe Cole said: "It's a big blow for us and the team. Our thoughts are with him.
"He's had a difficult 12 months with injury and now he's got a battle on his hands. Our thoughts are with him and his family. I hope he'll be back scoring goals for England soon."
England's problems were compounded when Rio Ferdinand was also replaced in the 56th minute after suffering a groin problem.
Eriksson said: "He had a little groin problem which we knew about at half-time. We tried it but it did not get better but I think he will be all right."
On top of that a match of high drama also saw Wayne Rooney substituted on 69 minutes, after which he punched the roof of the dug-out, kicked a water bottle and threw his boots to the ground in frustration.
Eriksson said: "I asked him why he did it and he said he was disappointed with himself because he thought he should have played better second half. It's not a problem at all.
"Rooney could have played longer today but it was his first game from the start and I couldn't risk overworking him because I don't want to risk him.
"He will be better and better. I'm sorry about Owen. But we have Walcott. And Gerrard and Joe Cole scored fantastic goals."
Joe Cole gave England the lead in a storming first half before Marcus Allback equalised with a header from a corner. Steven Gerrard then put England back ahead before Henrik Larsson equalised again in the 89th minute.
Eriksson added: "We did very well in the first half. We started badly in the second half and we suffered. We have to go on playing and defending better at set-pieces.
"But the most important thing is we won the group. We scored two fantastic goals but it is very annoying to concede two goals."
After the game Eriksson spoke to Swedish coach Lars Lagerback: "I told him 'Good luck for Saturday when they play Germany'. I said, 'Knock them out.'
Joe Cole added: "We should have killed the game in the first half. It was a good performance by us but there is a lot to work on.
"The goal was a good moment for me and for England. It sat up nice for me."
He also looked forward to Sunday's match against Ecuador.
He said: "It's going to be a tough game. They finished third in South American qualifying and have had two great performances. It's knockout, the business starts now and we can't afford to make any mistakes from set-pieces.
"But we are confident in our defenders and I'm sure that will be the last time we concede a goal from a set-piece."
Lagerback said: "England played well in the first half and we were too ambitious but we fought back well."